The Simpsons Apocalypse

In an entire episode of re-worked Bible stories, the final scene is fittingly apocalyptic.
The Apocalypse scene starts 20:40 into the episode, which you can watch here.

Marge: "Oh No! It's the Apocalypse! Bart, are you wearing clean underwear?"
Bart: "Not any more."
Lisa: "It's the rapture, and I never knew true love."
Homer: "And I never used those pizza coupons..."

With thanks to the Bellinghams